Synthetic bone substitute material comparable with xenogeneic material for bone tissue regeneration in oral cancer patients: First and preliminary histological, histomorphometrical and clinical results
Identifieur interne : 002185 ( Main/Exploration ); précédent : 002184; suivant : 002186Synthetic bone substitute material comparable with xenogeneic material for bone tissue regeneration in oral cancer patients: First and preliminary histological, histomorphometrical and clinical results
Auteurs : Shahram Ghanaati [Allemagne] ; Mike Barbeck [Allemagne] ; Jonas Lorenz [Allemagne] ; Stefan Stuebinger [Suisse] ; Oliver Seitz [Allemagne] ; Constantin Landes [Allemagne] ; Adorján F. Kovács [Allemagne] ; Charles J. Kirkpatrick [Allemagne] ; Robert A. Sader [Allemagne]Source :
- Annals of Maxillofacial Surgery [ 2231-0746 ] ; 2013.
Abstract
The present study was first to evaluate the material-specific cellular tissue response of patients with head and neck cancer to a nanocrystalline hydroxyapatite bone substitute NanoBone (NB) in comparison with a deproteinized bovine bone matrix Bio-Oss (BO) after implantation into the sinus cavity.
Eight patients with tumor resection for oral cancer and severely resorbed maxillary bone received materials according to a split mouth design for 6 months. Bone cores were harvested prior to implantation and analyzed histologically and histomorphometrically. Implant survival was followed-up to 2 years after placement.
Histologically, NB underwent a higher vascularization and induced significantly more tartrate-resistant acid phosphatase-positive (TRAP-positive) multinucleated giant cells when compared with BO, which induced mainly mononuclear cells. No significant difference was observed in the extent of new bone formation between both groups. The clinical follow-up showed undisturbed healing of all implants in the BO-group, whereas the loss of one implant was observed in the NB-group.
Within its limits, the present study showed for the first time that both material classes evaluated, despite their induction of different cellular tissue reactions, may be useful as augmentation materials for dental and maxillofacial surgical applications, particularly in patients who previously had oral cancer.
Url:
DOI: 10.4103/2231-0746.119221
PubMed: 24205471
PubMed Central: 3814660
Affiliations:
- Allemagne, Suisse
- District de Darmstadt, Hesse (Land), Rhénanie-Palatinat
- Francfort-sur-le-Main, Mayence
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 002824
- to stream Pmc, to step Curation: 002824
- to stream Pmc, to step Checkpoint: 001758
- to stream Ncbi, to step Merge: 004B19
- to stream Ncbi, to step Curation: 004B19
- to stream Ncbi, to step Checkpoint: 004B19
- to stream Main, to step Merge: 002196
- to stream Main, to step Curation: 002185
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Synthetic bone substitute material comparable with xenogeneic material for bone tissue regeneration in oral cancer patients: First and preliminary histological, histomorphometrical and clinical results</title><author><name sortKey="Ghanaati, Shahram" sort="Ghanaati, Shahram" uniqKey="Ghanaati S" first="Shahram" last="Ghanaati">Shahram Ghanaati</name><affiliation wicri:level="3"><nlm:aff id="aff1">Department for Oral, Cranio-Maxillofacial and Facial Plastic Surgery, Medical Center of the Goethe University Frankfurt, Frankfurt am Main, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department for Oral, Cranio-Maxillofacial and Facial Plastic Surgery, Medical Center of the Goethe University Frankfurt, Frankfurt am Main</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region><settlement type="city">Francfort-sur-le-Main</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff2">REPAIR-Lab, Institute of Pathology, University Medical Center, Johannes Gutenberg University, Mainz, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>REPAIR-Lab, Institute of Pathology, University Medical Center, Johannes Gutenberg University, Mainz</wicri:regionArea><placeName><region type="land" nuts="2">Rhénanie-Palatinat</region><settlement type="city">Mayence</settlement></placeName></affiliation></author><author><name sortKey="Barbeck, Mike" sort="Barbeck, Mike" uniqKey="Barbeck M" first="Mike" last="Barbeck">Mike Barbeck</name><affiliation wicri:level="3"><nlm:aff id="aff1">Department for Oral, Cranio-Maxillofacial and Facial Plastic Surgery, Medical Center of the Goethe University Frankfurt, Frankfurt am Main, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department for Oral, Cranio-Maxillofacial and Facial Plastic Surgery, Medical Center of the Goethe University Frankfurt, Frankfurt am Main</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region><settlement type="city">Francfort-sur-le-Main</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff2">REPAIR-Lab, Institute of Pathology, University Medical Center, Johannes Gutenberg University, Mainz, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>REPAIR-Lab, Institute of Pathology, University Medical Center, Johannes Gutenberg University, Mainz</wicri:regionArea><placeName><region type="land" nuts="2">Rhénanie-Palatinat</region><settlement type="city">Mayence</settlement></placeName></affiliation></author><author><name sortKey="Lorenz, Jonas" sort="Lorenz, Jonas" uniqKey="Lorenz J" first="Jonas" last="Lorenz">Jonas Lorenz</name><affiliation wicri:level="3"><nlm:aff id="aff1">Department for Oral, Cranio-Maxillofacial and Facial Plastic Surgery, Medical Center of the Goethe University Frankfurt, Frankfurt am Main, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department for Oral, Cranio-Maxillofacial and Facial Plastic Surgery, Medical Center of the Goethe University Frankfurt, Frankfurt am Main</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region><settlement type="city">Francfort-sur-le-Main</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff2">REPAIR-Lab, Institute of Pathology, University Medical Center, Johannes Gutenberg University, Mainz, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>REPAIR-Lab, Institute of Pathology, University Medical Center, Johannes Gutenberg University, Mainz</wicri:regionArea><placeName><region type="land" nuts="2">Rhénanie-Palatinat</region><settlement type="city">Mayence</settlement></placeName></affiliation></author><author><name sortKey="Stuebinger, Stefan" sort="Stuebinger, Stefan" uniqKey="Stuebinger S" first="Stefan" last="Stuebinger">Stefan Stuebinger</name><affiliation wicri:level="1"><nlm:aff id="aff3">Center for Applied Biotechnology and Molecular Medicine, Zurich, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Center for Applied Biotechnology and Molecular Medicine, Zurich</wicri:regionArea><wicri:noRegion>Zurich</wicri:noRegion></affiliation></author><author><name sortKey="Seitz, Oliver" sort="Seitz, Oliver" uniqKey="Seitz O" first="Oliver" last="Seitz">Oliver Seitz</name><affiliation wicri:level="3"><nlm:aff id="aff1">Department for Oral, Cranio-Maxillofacial and Facial Plastic Surgery, Medical Center of the Goethe University Frankfurt, Frankfurt am Main, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department for Oral, Cranio-Maxillofacial and Facial Plastic Surgery, Medical Center of the Goethe University Frankfurt, Frankfurt am Main</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region><settlement type="city">Francfort-sur-le-Main</settlement></placeName></affiliation></author><author><name sortKey="Landes, Constantin" sort="Landes, Constantin" uniqKey="Landes C" first="Constantin" last="Landes">Constantin Landes</name><affiliation wicri:level="3"><nlm:aff id="aff1">Department for Oral, Cranio-Maxillofacial and Facial Plastic Surgery, Medical Center of the Goethe University Frankfurt, Frankfurt am Main, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department for Oral, Cranio-Maxillofacial and Facial Plastic Surgery, Medical Center of the Goethe University Frankfurt, Frankfurt am Main</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region><settlement type="city">Francfort-sur-le-Main</settlement></placeName></affiliation></author><author><name sortKey="Kovacs, Adorjan F" sort="Kovacs, Adorjan F" uniqKey="Kovacs A" first="Adorján F." last="Kovács">Adorján F. Kovács</name><affiliation wicri:level="1"><nlm:aff id="aff4">Private Practice, Nauheim, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Private Practice, Nauheim</wicri:regionArea><wicri:noRegion>Nauheim</wicri:noRegion><wicri:noRegion>Nauheim</wicri:noRegion><wicri:noRegion>Nauheim</wicri:noRegion></affiliation></author><author><name sortKey="Kirkpatrick, Charles J" sort="Kirkpatrick, Charles J" uniqKey="Kirkpatrick C" first="Charles J." last="Kirkpatrick">Charles J. Kirkpatrick</name><affiliation wicri:level="3"><nlm:aff id="aff2">REPAIR-Lab, Institute of Pathology, University Medical Center, Johannes Gutenberg University, Mainz, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>REPAIR-Lab, Institute of Pathology, University Medical Center, Johannes Gutenberg University, Mainz</wicri:regionArea><placeName><region type="land" nuts="2">Rhénanie-Palatinat</region><settlement type="city">Mayence</settlement></placeName></affiliation></author><author><name sortKey="Sader, Robert A" sort="Sader, Robert A" uniqKey="Sader R" first="Robert A." last="Sader">Robert A. Sader</name><affiliation wicri:level="3"><nlm:aff id="aff1">Department for Oral, Cranio-Maxillofacial and Facial Plastic Surgery, Medical Center of the Goethe University Frankfurt, Frankfurt am Main, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department for Oral, Cranio-Maxillofacial and Facial Plastic Surgery, Medical Center of the Goethe University Frankfurt, Frankfurt am Main</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region><settlement type="city">Francfort-sur-le-Main</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24205471</idno><idno type="pmc">3814660</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3814660</idno><idno type="RBID">PMC:3814660</idno><idno type="doi">10.4103/2231-0746.119221</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">002824</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002824</idno><idno type="wicri:Area/Pmc/Curation">002824</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002824</idno><idno type="wicri:Area/Pmc/Checkpoint">001758</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001758</idno><idno type="wicri:Area/Ncbi/Merge">004B19</idno><idno type="wicri:Area/Ncbi/Curation">004B19</idno><idno type="wicri:Area/Ncbi/Checkpoint">004B19</idno><idno type="wicri:doubleKey">2231-0746:2013:Ghanaati S:synthetic:bone:substitute</idno><idno type="wicri:Area/Main/Merge">002196</idno><idno type="wicri:Area/Main/Curation">002185</idno><idno type="wicri:Area/Main/Exploration">002185</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Synthetic bone substitute material comparable with xenogeneic material for bone tissue regeneration in oral cancer patients: First and preliminary histological, histomorphometrical and clinical results</title><author><name sortKey="Ghanaati, Shahram" sort="Ghanaati, Shahram" uniqKey="Ghanaati S" first="Shahram" last="Ghanaati">Shahram Ghanaati</name><affiliation wicri:level="3"><nlm:aff id="aff1">Department for Oral, Cranio-Maxillofacial and Facial Plastic Surgery, Medical Center of the Goethe University Frankfurt, Frankfurt am Main, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department for Oral, Cranio-Maxillofacial and Facial Plastic Surgery, Medical Center of the Goethe University Frankfurt, Frankfurt am Main</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region><settlement type="city">Francfort-sur-le-Main</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff2">REPAIR-Lab, Institute of Pathology, University Medical Center, Johannes Gutenberg University, Mainz, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>REPAIR-Lab, Institute of Pathology, University Medical Center, Johannes Gutenberg University, Mainz</wicri:regionArea><placeName><region type="land" nuts="2">Rhénanie-Palatinat</region><settlement type="city">Mayence</settlement></placeName></affiliation></author><author><name sortKey="Barbeck, Mike" sort="Barbeck, Mike" uniqKey="Barbeck M" first="Mike" last="Barbeck">Mike Barbeck</name><affiliation wicri:level="3"><nlm:aff id="aff1">Department for Oral, Cranio-Maxillofacial and Facial Plastic Surgery, Medical Center of the Goethe University Frankfurt, Frankfurt am Main, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department for Oral, Cranio-Maxillofacial and Facial Plastic Surgery, Medical Center of the Goethe University Frankfurt, Frankfurt am Main</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region><settlement type="city">Francfort-sur-le-Main</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff2">REPAIR-Lab, Institute of Pathology, University Medical Center, Johannes Gutenberg University, Mainz, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>REPAIR-Lab, Institute of Pathology, University Medical Center, Johannes Gutenberg University, Mainz</wicri:regionArea><placeName><region type="land" nuts="2">Rhénanie-Palatinat</region><settlement type="city">Mayence</settlement></placeName></affiliation></author><author><name sortKey="Lorenz, Jonas" sort="Lorenz, Jonas" uniqKey="Lorenz J" first="Jonas" last="Lorenz">Jonas Lorenz</name><affiliation wicri:level="3"><nlm:aff id="aff1">Department for Oral, Cranio-Maxillofacial and Facial Plastic Surgery, Medical Center of the Goethe University Frankfurt, Frankfurt am Main, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department for Oral, Cranio-Maxillofacial and Facial Plastic Surgery, Medical Center of the Goethe University Frankfurt, Frankfurt am Main</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region><settlement type="city">Francfort-sur-le-Main</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff2">REPAIR-Lab, Institute of Pathology, University Medical Center, Johannes Gutenberg University, Mainz, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>REPAIR-Lab, Institute of Pathology, University Medical Center, Johannes Gutenberg University, Mainz</wicri:regionArea><placeName><region type="land" nuts="2">Rhénanie-Palatinat</region><settlement type="city">Mayence</settlement></placeName></affiliation></author><author><name sortKey="Stuebinger, Stefan" sort="Stuebinger, Stefan" uniqKey="Stuebinger S" first="Stefan" last="Stuebinger">Stefan Stuebinger</name><affiliation wicri:level="1"><nlm:aff id="aff3">Center for Applied Biotechnology and Molecular Medicine, Zurich, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Center for Applied Biotechnology and Molecular Medicine, Zurich</wicri:regionArea><wicri:noRegion>Zurich</wicri:noRegion></affiliation></author><author><name sortKey="Seitz, Oliver" sort="Seitz, Oliver" uniqKey="Seitz O" first="Oliver" last="Seitz">Oliver Seitz</name><affiliation wicri:level="3"><nlm:aff id="aff1">Department for Oral, Cranio-Maxillofacial and Facial Plastic Surgery, Medical Center of the Goethe University Frankfurt, Frankfurt am Main, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department for Oral, Cranio-Maxillofacial and Facial Plastic Surgery, Medical Center of the Goethe University Frankfurt, Frankfurt am Main</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region><settlement type="city">Francfort-sur-le-Main</settlement></placeName></affiliation></author><author><name sortKey="Landes, Constantin" sort="Landes, Constantin" uniqKey="Landes C" first="Constantin" last="Landes">Constantin Landes</name><affiliation wicri:level="3"><nlm:aff id="aff1">Department for Oral, Cranio-Maxillofacial and Facial Plastic Surgery, Medical Center of the Goethe University Frankfurt, Frankfurt am Main, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department for Oral, Cranio-Maxillofacial and Facial Plastic Surgery, Medical Center of the Goethe University Frankfurt, Frankfurt am Main</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region><settlement type="city">Francfort-sur-le-Main</settlement></placeName></affiliation></author><author><name sortKey="Kovacs, Adorjan F" sort="Kovacs, Adorjan F" uniqKey="Kovacs A" first="Adorján F." last="Kovács">Adorján F. Kovács</name><affiliation wicri:level="1"><nlm:aff id="aff4">Private Practice, Nauheim, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Private Practice, Nauheim</wicri:regionArea><wicri:noRegion>Nauheim</wicri:noRegion><wicri:noRegion>Nauheim</wicri:noRegion><wicri:noRegion>Nauheim</wicri:noRegion></affiliation></author><author><name sortKey="Kirkpatrick, Charles J" sort="Kirkpatrick, Charles J" uniqKey="Kirkpatrick C" first="Charles J." last="Kirkpatrick">Charles J. Kirkpatrick</name><affiliation wicri:level="3"><nlm:aff id="aff2">REPAIR-Lab, Institute of Pathology, University Medical Center, Johannes Gutenberg University, Mainz, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>REPAIR-Lab, Institute of Pathology, University Medical Center, Johannes Gutenberg University, Mainz</wicri:regionArea><placeName><region type="land" nuts="2">Rhénanie-Palatinat</region><settlement type="city">Mayence</settlement></placeName></affiliation></author><author><name sortKey="Sader, Robert A" sort="Sader, Robert A" uniqKey="Sader R" first="Robert A." last="Sader">Robert A. Sader</name><affiliation wicri:level="3"><nlm:aff id="aff1">Department for Oral, Cranio-Maxillofacial and Facial Plastic Surgery, Medical Center of the Goethe University Frankfurt, Frankfurt am Main, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department for Oral, Cranio-Maxillofacial and Facial Plastic Surgery, Medical Center of the Goethe University Frankfurt, Frankfurt am Main</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region><settlement type="city">Francfort-sur-le-Main</settlement></placeName></affiliation></author></analytic><series><title level="j">Annals of Maxillofacial Surgery</title><idno type="ISSN">2231-0746</idno><idno type="eISSN">2249-3816</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="st1"><title>Background:</title><p>The present study was first to evaluate the material-specific cellular tissue response of patients with head and neck cancer to a nanocrystalline hydroxyapatite bone substitute NanoBone (NB) in comparison with a deproteinized bovine bone matrix Bio-Oss (BO) after implantation into the sinus cavity.</p></sec><sec id="st2"><title>Materials and Methods:</title><p>Eight patients with tumor resection for oral cancer and severely resorbed maxillary bone received materials according to a split mouth design for 6 months. Bone cores were harvested prior to implantation and analyzed histologically and histomorphometrically. Implant survival was followed-up to 2 years after placement.</p></sec><sec id="st3"><title>Results:</title><p>Histologically, NB underwent a higher vascularization and induced significantly more tartrate-resistant acid phosphatase-positive (TRAP-positive) multinucleated giant cells when compared with BO, which induced mainly mononuclear cells. No significant difference was observed in the extent of new bone formation between both groups. The clinical follow-up showed undisturbed healing of all implants in the BO-group, whereas the loss of one implant was observed in the NB-group.</p></sec><sec id="st4"><title>Conclusions:</title><p>Within its limits, the present study showed for the first time that both material classes evaluated, despite their induction of different cellular tissue reactions, may be useful as augmentation materials for dental and maxillofacial surgical applications, particularly in patients who previously had oral cancer.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Jemal, A" uniqKey="Jemal A">A Jemal</name></author><author><name sortKey="Siegel, R" uniqKey="Siegel R">R Siegel</name></author><author><name sortKey="Xu, J" uniqKey="Xu J">J Xu</name></author><author><name sortKey="Ward, E" uniqKey="Ward E">E Ward</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Damien, Cj" uniqKey="Damien C">CJ Damien</name></author><author><name sortKey="Parsons, Jr" uniqKey="Parsons J">JR Parsons</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Younger, Em" uniqKey="Younger E">EM Younger</name></author><author><name sortKey="Chapman, Mw" uniqKey="Chapman M">MW Chapman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ghanaati, S" uniqKey="Ghanaati S">S Ghanaati</name></author><author><name sortKey="Orth, C" uniqKey="Orth C">C Orth</name></author><author><name sortKey="Barbeck, M" uniqKey="Barbeck M">M Barbeck</name></author><author><name sortKey="Willershausen, I" uniqKey="Willershausen I">I Willershausen</name></author><author><name sortKey="Thimm, Bw" uniqKey="Thimm B">BW Thimm</name></author><author><name sortKey="Booms, P" uniqKey="Booms P">P Booms</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ghanaati, S" uniqKey="Ghanaati S">S Ghanaati</name></author><author><name sortKey="Udeabor, Se" uniqKey="Udeabor S">SE Udeabor</name></author><author><name sortKey="Barbeck, M" uniqKey="Barbeck M">M Barbeck</name></author><author><name sortKey="Willershausen, I" uniqKey="Willershausen I">I Willershausen</name></author><author><name sortKey="Kuenzel, O" uniqKey="Kuenzel O">O Kuenzel</name></author><author><name sortKey="Sader, Ra" uniqKey="Sader R">RA Sader</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stubinger, S" uniqKey="Stubinger S">S Stübinger</name></author><author><name sortKey="Ghanaati, S" uniqKey="Ghanaati S">S Ghanaati</name></author><author><name sortKey="Orth, C" uniqKey="Orth C">C Orth</name></author><author><name sortKey="Hilbig, U" uniqKey="Hilbig U">U Hilbig</name></author><author><name sortKey="Saldamli, B" uniqKey="Saldamli B">B Saldamli</name></author><author><name sortKey="Biesterfeld, S" uniqKey="Biesterfeld S">S Biesterfeld</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ghanaati, S" uniqKey="Ghanaati S">S Ghanaati</name></author><author><name sortKey="Barbeck, M" uniqKey="Barbeck M">M Barbeck</name></author><author><name sortKey="Willershausen, I" uniqKey="Willershausen I">I Willershausen</name></author><author><name sortKey="Thimm, B" uniqKey="Thimm B">B Thimm</name></author><author><name sortKey="Stuebinger, S" uniqKey="Stuebinger S">S Stuebinger</name></author><author><name sortKey="Korzinskas, T" uniqKey="Korzinskas T">T Korzinskas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jensen, Ss" uniqKey="Jensen S">SS Jensen</name></author><author><name sortKey="Aaboe, M" uniqKey="Aaboe M">M Aaboe</name></author><author><name sortKey="Pinholt, Em" uniqKey="Pinholt E">EM Pinholt</name></author><author><name sortKey="Hj Rting Hansen, E" uniqKey="Hj Rting Hansen E">E Hjørting-Hansen</name></author><author><name sortKey="Melsen, F" uniqKey="Melsen F">F Melsen</name></author><author><name sortKey="Ruyter, Ie" uniqKey="Ruyter I">IE Ruyter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Norton, Mr" uniqKey="Norton M">MR Norton</name></author><author><name sortKey="Odell, Ew" uniqKey="Odell E">EW Odell</name></author><author><name sortKey="Thompson, Id" uniqKey="Thompson I">ID Thompson</name></author><author><name sortKey="Cook, Rj" uniqKey="Cook R">RJ Cook</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Valentini, P" uniqKey="Valentini P">P Valentini</name></author><author><name sortKey="Abensur, Dj" uniqKey="Abensur D">DJ Abensur</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mellonig, Jt" uniqKey="Mellonig J">JT Mellonig</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gerber, T" uniqKey="Gerber T">T Gerber</name></author><author><name sortKey="Traykova, T" uniqKey="Traykova T">T Traykova</name></author><author><name sortKey="Henkel, Ko" uniqKey="Henkel K">KO Henkel</name></author><author><name sortKey="Bienengraeber, V" uniqKey="Bienengraeber V">V Bienengraeber</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gerike, W" uniqKey="Gerike W">W Gerike</name></author><author><name sortKey="Bienengr Ber, V" uniqKey="Bienengr Ber V">V Bienengräber</name></author><author><name sortKey="Henkel, Ko" uniqKey="Henkel K">KO Henkel</name></author><author><name sortKey="Bayerlein, T" uniqKey="Bayerlein T">T Bayerlein</name></author><author><name sortKey="Proff, P" uniqKey="Proff P">P Proff</name></author><author><name sortKey="Gedrange, T" uniqKey="Gedrange T">T Gedrange</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ghanaati, S" uniqKey="Ghanaati S">S Ghanaati</name></author><author><name sortKey="Barbeck, M" uniqKey="Barbeck M">M Barbeck</name></author><author><name sortKey="Detsch, R" uniqKey="Detsch R">R Detsch</name></author><author><name sortKey="Deisinger, U" uniqKey="Deisinger U">U Deisinger</name></author><author><name sortKey="Hilbig, U" uniqKey="Hilbig U">U Hilbig</name></author><author><name sortKey="Rausch, V" uniqKey="Rausch V">V Rausch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ghanaati, S" uniqKey="Ghanaati S">S Ghanaati</name></author><author><name sortKey="Barbeck, M" uniqKey="Barbeck M">M Barbeck</name></author><author><name sortKey="Orth, C" uniqKey="Orth C">C Orth</name></author><author><name sortKey="Willershausen, I" uniqKey="Willershausen I">I Willershausen</name></author><author><name sortKey="Thimm, Bw" uniqKey="Thimm B">BW Thimm</name></author><author><name sortKey="Hoffmann, C" uniqKey="Hoffmann C">C Hoffmann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ghanaati, S" uniqKey="Ghanaati S">S Ghanaati</name></author><author><name sortKey="Schlee, M" uniqKey="Schlee M">M Schlee</name></author><author><name sortKey="Webber, Mj" uniqKey="Webber M">MJ Webber</name></author><author><name sortKey="Willershausen, I" uniqKey="Willershausen I">I Willershausen</name></author><author><name sortKey="Barbeck, M" uniqKey="Barbeck M">M Barbeck</name></author><author><name sortKey="Balic, E" uniqKey="Balic E">E Balic</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Neukam, Fw" uniqKey="Neukam F">FW Neukam</name></author><author><name sortKey="Esser, E" uniqKey="Esser E">E Esser</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Anderson, Jm" uniqKey="Anderson J">JM Anderson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ghanaati, S" uniqKey="Ghanaati S">S Ghanaati</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ghanaati, S" uniqKey="Ghanaati S">S Ghanaati</name></author><author><name sortKey="Orth, C" uniqKey="Orth C">C Orth</name></author><author><name sortKey="Unger, Re" uniqKey="Unger R">RE Unger</name></author><author><name sortKey="Barbeck, M" uniqKey="Barbeck M">M Barbeck</name></author><author><name sortKey="Webber, Mj" uniqKey="Webber M">MJ Webber</name></author><author><name sortKey="Motta, A" uniqKey="Motta A">A Motta</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Anderson, Jm" uniqKey="Anderson J">JM Anderson</name></author><author><name sortKey="Rodriguez, A" uniqKey="Rodriguez A">A Rodriguez</name></author><author><name sortKey="Chang, Dt" uniqKey="Chang D">DT Chang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ghanaati, S" uniqKey="Ghanaati S">S Ghanaati</name></author><author><name sortKey="Unger, Re" uniqKey="Unger R">RE Unger</name></author><author><name sortKey="Webber, Mj" uniqKey="Webber M">MJ Webber</name></author><author><name sortKey="Barbeck, M" uniqKey="Barbeck M">M Barbeck</name></author><author><name sortKey="Orth, C" uniqKey="Orth C">C Orth</name></author><author><name sortKey="Kirkpatrick, Ja" uniqKey="Kirkpatrick J">JA Kirkpatrick</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ferrara, N" uniqKey="Ferrara N">N Ferrara</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Langstaff, S" uniqKey="Langstaff S">S Langstaff</name></author><author><name sortKey="Sayer, M" uniqKey="Sayer M">M Sayer</name></author><author><name sortKey="Smith, Tj" uniqKey="Smith T">TJ Smith</name></author><author><name sortKey="Pugh, Sm" uniqKey="Pugh S">SM Pugh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lu, J" uniqKey="Lu J">J Lu</name></author><author><name sortKey="Descamps, M" uniqKey="Descamps M">M Descamps</name></author><author><name sortKey="Dejou, J" uniqKey="Dejou J">J Dejou</name></author><author><name sortKey="Koubi, G" uniqKey="Koubi G">G Koubi</name></author><author><name sortKey="Hardouin, P" uniqKey="Hardouin P">P Hardouin</name></author><author><name sortKey="Lemaitre, J" uniqKey="Lemaitre J">J Lemaitre</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Greenwald, As" uniqKey="Greenwald A">AS Greenwald</name></author><author><name sortKey="Boden, Sd" uniqKey="Boden S">SD Boden</name></author><author><name sortKey="Goldberg, Vm" uniqKey="Goldberg V">VM Goldberg</name></author><author><name sortKey="Khan, Y" uniqKey="Khan Y">Y Khan</name></author><author><name sortKey="Laurencin, Ct" uniqKey="Laurencin C">CT Laurencin</name></author><author><name sortKey="Rosier, Rn" uniqKey="Rosier R">RN Rosier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nuss, Km" uniqKey="Nuss K">KM Nuss</name></author><author><name sortKey="Von Rechenberg, B" uniqKey="Von Rechenberg B">B von Rechenberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Phemister, Db" uniqKey="Phemister D">DB Phemister</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barrere, F" uniqKey="Barrere F">F Barrère</name></author><author><name sortKey="Van Blitterswijk, Ca" uniqKey="Van Blitterswijk C">CA van Blitterswijk</name></author><author><name sortKey="De Groot, K" uniqKey="De Groot K">K de Groot</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hayman, Ar" uniqKey="Hayman A">AR Hayman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kular, J" uniqKey="Kular J">J Kular</name></author><author><name sortKey="Tickner, J" uniqKey="Tickner J">J Tickner</name></author><author><name sortKey="Chim, Sm" uniqKey="Chim S">SM Chim</name></author><author><name sortKey="Xu, J" uniqKey="Xu J">J Xu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Garimella, R" uniqKey="Garimella R">R Garimella</name></author><author><name sortKey="Tague, Se" uniqKey="Tague S">SE Tague</name></author><author><name sortKey="Zhang, J" uniqKey="Zhang J">J Zhang</name></author><author><name sortKey="Belibi, F" uniqKey="Belibi F">F Belibi</name></author><author><name sortKey="Nahar, N" uniqKey="Nahar N">N Nahar</name></author><author><name sortKey="Sun, Bh" uniqKey="Sun B">BH Sun</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sims, Na" uniqKey="Sims N">NA Sims</name></author><author><name sortKey="Walsh, Nc" uniqKey="Walsh N">NC Walsh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sanchez Fernandez, Ma" uniqKey="Sanchez Fernandez M">MA Sanchez-Fernandez</name></author><author><name sortKey="Gallois, A" uniqKey="Gallois A">A Gallois</name></author><author><name sortKey="Riedl, T" uniqKey="Riedl T">T Riedl</name></author><author><name sortKey="Jurdic, P" uniqKey="Jurdic P">P Jurdic</name></author><author><name sortKey="Hoflack, B" uniqKey="Hoflack B">B Hoflack</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cao, X" uniqKey="Cao X">X Cao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ghanaati, Sm" uniqKey="Ghanaati S">SM Ghanaati</name></author><author><name sortKey="Thimm, Bw" uniqKey="Thimm B">BW Thimm</name></author><author><name sortKey="Unger, Re" uniqKey="Unger R">RE Unger</name></author><author><name sortKey="Orth, C" uniqKey="Orth C">C Orth</name></author><author><name sortKey="Kohler, T" uniqKey="Kohler T">T Kohler</name></author><author><name sortKey="Barbeck, M" uniqKey="Barbeck M">M Barbeck</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sartori, S" uniqKey="Sartori S">S Sartori</name></author><author><name sortKey="Silvestri, M" uniqKey="Silvestri M">M Silvestri</name></author><author><name sortKey="Forni, F" uniqKey="Forni F">F Forni</name></author><author><name sortKey="Icaro, Cornaglia A" uniqKey="Icaro C">Cornaglia A Icaro</name></author><author><name sortKey="Tesei, P" uniqKey="Tesei P">P Tesei</name></author><author><name sortKey="Cattaneo, V" uniqKey="Cattaneo V">V Cattaneo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yildirim, M" uniqKey="Yildirim M">M Yildirim</name></author><author><name sortKey="Spiekermann, H" uniqKey="Spiekermann H">H Spiekermann</name></author><author><name sortKey="Biesterfeld, S" uniqKey="Biesterfeld S">S Biesterfeld</name></author><author><name sortKey="Edelhoff, D" uniqKey="Edelhoff D">D Edelhoff</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hallman, M" uniqKey="Hallman M">M Hallman</name></author><author><name sortKey="Lundgren, S" uniqKey="Lundgren S">S Lundgren</name></author><author><name sortKey="Sennerby, L" uniqKey="Sennerby L">L Sennerby</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Traini, T" uniqKey="Traini T">T Traini</name></author><author><name sortKey="Valentini, P" uniqKey="Valentini P">P Valentini</name></author><author><name sortKey="Iezzi, G" uniqKey="Iezzi G">G Iezzi</name></author><author><name sortKey="Piattelli, A" uniqKey="Piattelli A">A Piattelli</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li><li>Suisse</li></country><region><li>District de Darmstadt</li><li>Hesse (Land)</li><li>Rhénanie-Palatinat</li></region><settlement><li>Francfort-sur-le-Main</li><li>Mayence</li></settlement></list><tree><country name="Allemagne"><region name="Hesse (Land)"><name sortKey="Ghanaati, Shahram" sort="Ghanaati, Shahram" uniqKey="Ghanaati S" first="Shahram" last="Ghanaati">Shahram Ghanaati</name></region><name sortKey="Barbeck, Mike" sort="Barbeck, Mike" uniqKey="Barbeck M" first="Mike" last="Barbeck">Mike Barbeck</name><name sortKey="Barbeck, Mike" sort="Barbeck, Mike" uniqKey="Barbeck M" first="Mike" last="Barbeck">Mike Barbeck</name><name sortKey="Ghanaati, Shahram" sort="Ghanaati, Shahram" uniqKey="Ghanaati S" first="Shahram" last="Ghanaati">Shahram Ghanaati</name><name sortKey="Kirkpatrick, Charles J" sort="Kirkpatrick, Charles J" uniqKey="Kirkpatrick C" first="Charles J." last="Kirkpatrick">Charles J. Kirkpatrick</name><name sortKey="Kovacs, Adorjan F" sort="Kovacs, Adorjan F" uniqKey="Kovacs A" first="Adorján F." last="Kovács">Adorján F. Kovács</name><name sortKey="Landes, Constantin" sort="Landes, Constantin" uniqKey="Landes C" first="Constantin" last="Landes">Constantin Landes</name><name sortKey="Lorenz, Jonas" sort="Lorenz, Jonas" uniqKey="Lorenz J" first="Jonas" last="Lorenz">Jonas Lorenz</name><name sortKey="Lorenz, Jonas" sort="Lorenz, Jonas" uniqKey="Lorenz J" first="Jonas" last="Lorenz">Jonas Lorenz</name><name sortKey="Sader, Robert A" sort="Sader, Robert A" uniqKey="Sader R" first="Robert A." last="Sader">Robert A. Sader</name><name sortKey="Seitz, Oliver" sort="Seitz, Oliver" uniqKey="Seitz O" first="Oliver" last="Seitz">Oliver Seitz</name></country><country name="Suisse"><noRegion><name sortKey="Stuebinger, Stefan" sort="Stuebinger, Stefan" uniqKey="Stuebinger S" first="Stefan" last="Stuebinger">Stefan Stuebinger</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/EdenteV2/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002185 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002185 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= EdenteV2
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:3814660
|texte= Synthetic bone substitute material comparable with xenogeneic material for bone tissue regeneration in oral cancer patients: First and preliminary histological, histomorphometrical and clinical results
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:24205471" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a EdenteV2
| This area was generated with Dilib version V0.6.32. |  |